There is very limited experience to date with deliberate overdose. The symptoms described in connection with an oral dose of 280mg were gastrointestinal symptoms and weakness. Single oral doses of 80mg esomeprazole and intravenous doses of 308mg esomeprazole over 24 hours were uneventful. No specific antidote is known. Esomeprazole is extensively plasma protein bound and is therefore not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilized.
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